In response to infection, Toll-like receptors (TLRs), especially TLR4 on immune cells (ICs) play a critical role in pathogen recognition by binding to the lipopolysaccharide (LPS) derived from bacteria, which is the endotoxin as an important pathogen-associated molecular pattern causing sepsis through TLR4 signaling [15]. This evidence concerns the gene TLR4 and Sepsis.