WNT3A and metabolic dysfunction-associated steatohepatitis: In conclusion, macrophage infiltration and activation seem to have a key role in the progression toward NASH in pNAFLD; the induction of the pro-inflammatory macrophage activation could trigger HPC proliferation and the activation of pro-fibrogenetic loop; the administration of dietary DHA influences macrophage activation and could have a role in the modulation of HPC response by Wnt3a production.