CCR2 and congenital secretory chloride diarrhea 1: Although a key role for classical monocytes and the CCR2/chemokine (C-C motif) ligand (CCL)2 axis in driving liver inflammation and fibrogenesis has been demonstrated in mice [2, 4, 5], preferential accumulation of hepatic and, in some studies peripheral, CD16+ monocytes has been reported in human CLD [8, 11, 17, 18], especially in areas of active inflammation and fibrosis [19].