Due to the high prevalence of colorectal cancers in Saudi Arabian population, we examined four commonly studied polymorphic loci, rs1544410 (BsmI), rs2228570 (FokI), rs7975232 (ApaI) and rs731236 (TaqI) in the VDR gene for a possible association with the risk of developing this malignancy. This evidence concerns the gene VDR and colorectal cancer.