While we observed the ‘C’ allele of VDR-ApaI to confer 77% increased risk for CRC in patients >57 years of age at the time of disease diagnosis, a recent meta-analysis by Serrano et al did not identify higher risk of CRC with VDR-ApaI but found a significant association with VDR-TaqI polymorphism [44]. The gene discussed is VDR; the disease is colorectal carcinoma.