EPAS1 and prostate cancer: In response to a lack of oxygen, an array of transcriptional responses is elicited via the hypoxia inducible factors (HIFs) HIF1-α and HIF-2α.98 In prostate cancer cells, hypoxic treatment resulted in stabilization of HIF1-α and HIF-2α, as well as upregulation of several transcription factors, including Nanog and Oct3/4.99