IFN-γ levels were significantly lower among ALS cases compared to controls (odds ratio [OR] 0.09, 95% CI 0.01–0.62, p = 0.02), while IL-6 (OR 18.55, 95% CI 1.37–251.95, p = 0.03), TNF-α (OR 35.78, 95% CI 1.86–689.20, p = 0.02), IL-4 (OR 90.90, 95% CI 1.25–6,603.62, p = 0.04), and IL-13 (OR 20.69, 95% CI 0.65–656.10, p = 0.086) were higher in ALS cases compared to controls. This evidence concerns the gene IFNG and amyotrophic lateral sclerosis.