It has previously been shown that CSF hosts relevant components of ALS immunoreactivity,19 including the regulation of the proinflammatory and neutrophil activator IL-8 linked to shorter disease duration and of the monocyte chemoattractant protein-1 (MCP-1) associated with prolonged survival.34 CSF is unanimously considered the most reliable source of biological signals of neurodegeneration for its anatomical contiguity to affected nervous tissues; it is naturally enriched of by-products of neuronal destruction or remodeling. This evidence concerns the gene CXCL8 and amyotrophic lateral sclerosis.