Patients with ALS at earlier disease stage (with higher ALSFRS-R score) were reported to have higher CK levels (ρ: 0.401, p = 0.0001) and lower CRP (ρ: −0.273, p = 0.008), TNF-α (ρ: −0.269, p = 0.009), and IL-6 (ρ: −0.217, p = 0.001) levels. The gene discussed is TNF; the disease is amyotrophic lateral sclerosis.