IL5 and amyotrophic lateral sclerosis: IL-5 and other cytokines driving the more benign form of inflammation defined as Th2 have not been reported to change in plasma expression after exercise.27 Since high CK plasma levels are also associated with better neurologic function (higher ALSFRS-R score) and slower progression rate in our patients with ALS, the correlation between CK and IL-5 expression may be indicative of neurorestorative mechanisms rather than being a measure of neuromuscular dysfunction.