CRP and amyotrophic lateral sclerosis: The pathologic process in ALS develops in distant anatomical regions either simultaneously or as a sequential process.2 Early ALS pathology is sensed by the innate immune system, with the activation of microglia, T-cells, dendritic, and antigen-presenting cells in corticospinal tracts and in the motor cortex3 and the release of inflammatory markers such as cytokines, C-reactive protein (CRP), and ferritin.4, –, 6