CD8A and amyotrophic lateral sclerosis: The reported increase of NK and CD8+ T cells in the blood of patients with ALS supports not only the important contribution of the innate immune system in the development of ALS, but also a potential role for IL-2.9,32 The interplay among IL-2, Treg, NK, and cytotoxic T cells is at the center of intense research into potential immunomodulatory therapeutic strategies in ALS.