CK, ferritin, TNF-α, IL-1β, IL-2, IL-8, IL-12p70, IL-4, IL-5, IL-10, and IL-13 were all found to be significantly increased, while IFN-γ was significantly decreased in plasma from patients with ALS compared with controls in both basic and multivariate models. This evidence concerns the gene IL1B and amyotrophic lateral sclerosis.