Recently, CXCR4 overexpression was reported to be associated with decreased survival of mice intravenously injected with DLBCL cells [18] and, importantly, with poor prognosis in a cohort of 94 DLBCL patients treated with rituximab-containing regimens [18] and a training/validation cohort of 468/275 DLBCL patients treated with the R-CHOP regimen [19]. This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.