Based on the promising findings of this study, implying that the CXCR4 antagonist plerixafor synergistically enhances the anti-proliferative/pro-apoptotic effect of rituximab on DLBCL cells, it seems interesting to further explore the effect of combining rituximab with CXCR4 antagonism. This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.