AKT2 and hepatocellular carcinoma: The lack of downregulation in Timp 1 by Akt2 deletion and its decline in 12- vs. 9-month-old mice may be related to its potential role in tumorigenesis as all Pten null mice developed tumors at 12 months of age and Timp 1 has been shown to inhibit mitogenesis in HCC [9].