As shown in Figure 1B, HOTAIRM1 expression were decreased in tumour tissues compared with matched normal tissues, Among 407 pairs of samples, HOTAIRM1 expression in tumours was down‐regulated in 350 samples (350/407, 86%), and as shown in Figure 1C, there were 194 colon cancer samples and 156 rectum cancer samples expressing low level HOTAIRM1. This evidence concerns the gene HOTAIRM1 and malignant colon neoplasm.