Several causative desmosome mutations of genes have been discovered in ARVC, including plakoglobin (PG), desmoplakin (DSP), plakophilin-2 (PKP2), desmoglein-2 (DSG2) and desmocollin-2 (DSC2)1, 4. The gene discussed is DSC2; the disease is arrhythmogenic right ventricular cardiomyopathy.