This aspect has been characterized extensively in AD, where tau accumulation is initiated in the locus coeruleus of the brainstem, before appearing in transentorhinal and entorhinal regions of the temporal lobe, followed by inclusions in the hippocampus and parts of the neocortex and, in the most severe cases, affecting almost the entire neocortex (reviewed in (Braak and Tredici 2011; Brettschneider et al. The gene discussed is MAPT; the disease is Alzheimer disease.