MAPT and Cognitive impairment: 2014). In the context of AD, exposing cortical cultures to synthetic preparations of Aβ oligomers was found to induce mislocalization of tau into spines under resting conditions, abrogating subsequent activity‐dependent synaptic tau translocation (Frandemiche et al. 2014). In another study, P301L mutant tau expression was targeted predominantly to layer II and III neurons of the entorhinal cortex, leading to ultrastructural synaptic alterations in hippocampal circuits, in the absence of robust cognitive deficits (Harris et al. 2012).