1995). In this model, the expression of the longest human tau isoform (2N4R) driven by the neuron‐specific promoter mThy1 was able to recapitulate key features of tauopathies, such as the presence of hyperphosphorylated tau mislocalized to neuronal cell bodies and dendrites (Götz et al. 1995). However, NFTs were not detected. Similar findings were obtained in a more advanced model, ALZ17, where the expression of human 2N4R under the control of the stronger hThy1.2 promoter led to signs of Wallerian degeneration and neurogenic muscle atrophy (Probst et al. 2000). Here, MAPT is linked to tauopathy.