CD8A and neoplasm: The pool of lymphocytes used for adoptive immunotherapy can be derived from any of the CD8+ subsets, including tumor-infiltrating lymphocytes (TILs), naive T cells (TN), and antigen-experienced memory T cells (TM), which can be divided into central memory (TCM) and effector memory (TEM) subsets that differ in phenotype, homing, and function8.