To generate convincing information, we in this study decided to employ a meta‐analytical method to assess the association of six widely evaluated non‐synonymous coding variants from three DNA repair genes, that is, XRCC1 (gene ID: 7515), XRCC3 (gene ID: 7517) and XPD (gene ID: 2068), in susceptibility to hepatocellular carcinoma, by pooling the summarized data from 20 English articles from medical literature. The gene discussed is ERCC2; the disease is hepatocellular carcinoma.