Furthermore, accumulating evidence has indicated the effect of herbal products on myocardial fibrosis and heart failure, and that oxymatrine (extracted from a traditional Chinese herb Sophora japonica) protected against myocardial fibrosis through the modulation of the TGF‐β(1)‐Smads signal pathway following AMI for 4 weeks 31. This evidence concerns the gene TGFB1 and Myocardial fibrosis.