We recently reported the association of a rare variant in BTNL2 with CD and ulcerative colitis.30 The rare missense variant (p.G454C) is not in linkage disequilibrium with the common splicing variant, and is thus likely to be an independent effect, but further supports a potential role for BTNL2 in these related disorders. The gene discussed is BTNL2; the disease is ulcerative colitis.