NOD2 and Cowden disease: They found that 4 of 12 OFG patients with concurrent CD carried one of these variants, whereas none of the 17 OFG patients without concurrent CD carried any risk variant, suggesting that these 2 groups of patients might be genetically distinct.15 However, the more recently discovered CD-associated NOD2 variants (p.M863V, p.D825S, p.R703C, p.S431L, p.V793M, and p.R311W) were not considered in this study; neither was the possible contribution of the novel variants in NOD2. The authors emphasized that these findings needed to be confirmed in a larger cohort of well-defined patients.