However, there was an age-dependant decrease in thresholds to noxious stimulation in the hot-plate test, which also involves supraspinal integration of nociceptive signals.13 Consistent with these observations, reduced sensitivity to noxious thermal stimuli has been observed to occur before any changes in mechanical nociceptive thresholds in the CRND8 model of AD41 and by us in the tail immersion test in TASTPM mice.8 Therefore, there may be a correlation between impaired nociceptive responses and an increase in APP/Aβ expression in the spinal cord along with cognitive impairment. Here, APP is linked to Cognitive impairment.