APP and Alzheimer disease: Previous studies have reported Aβ pathology in the 5XFAD and Tg2576 transgenic mouse models of AD, but have mainly focused on the dorsal column or the ventral horn and suggested an association between intraneuronal Aβ and motor impairment.21,39,47 Differently, in this study despite the accumulation of APP/Aβ in ventral horns, no gross motor deficits were detected in the TASTPM mice using the accelerating RotoRod test.