Moreover, approximately 2% of the cases were carriersof a clearly pathogenic mutation in LDLR, suggesting that these patients had a diagnosisof familial hypercholesterolemia.2 In abroader sense, it is estimated that approximately 5% of AMIs in patients aged < 60years may be due to familial hypercholesterolemia, a figure that can increase up to 20%when acute coronary events affect individuals younger than 45 years.5 Here, LDLR is linked to familial hypercholesterolemia.