Charles et al. evaluated other relevant clinicaloutcomes and reported that the decrease in the levels of PCT between the second andthird days of antibiotic treatment was an independent predictor of the response toempirical antimicrobial therapy and was also associated with longersurvival.(24) Outside theICU, the kinetics of PCT as a predictor of mortality in patients with sepsis alsoachieved positive results. The gene discussed is CALCA; the disease is Sepsis.