Combined with classical scores,these markers can be helpful in therapeutic decisions about the place of treatment(i.e., ICU or ward), antibiotic coverage, and length of therapy.(10) One of the most tested biomarkersis procalcitonin (PCT), which has been evaluated in several clinical studies onpatients with sepsis.(10,11) Increased serum PCT levels havebeen associated with the presence, severity, and extent of systemic bacterialinfections.(12,13) In addition, PCT increase isdependent on the cytokine cascade and can consequently be quickly neutralized byantibiotics. Here, CALCA is linked to Sepsis.