CALCA and Sepsis: In a recently published study, 130 ICU patients with severesepsis and septic shock were monitored for 18 months.(23) PCT clearance at 24 and 48 hours after thediagnosis of sepsis was significantly higher among survivors, with an area under thecurve (AUC) of 0.76 for the prediction of mortality in the ICU, compared with 0.68for the change in the SOFA score.