MMP-9 is thought to play an important role in HT29 and Hep-2 cancer cell migration and invasion [34,35], and our findings indicated that mogroside IVe treatment downregulatedMMP-9 expression in HT29 and Hep-2 cells both in vitro (Figure 3e,f) and in vivo (Figure 6c,d). This evidence concerns the gene MMP9 and cancer.