LEP and obesity due to melanocortin 4 receptor deficiency: The L. rhamnosus-induced weight loss in women was associated not only with significant reductions in fat mass and circulating leptin concentrations but also with the relative abundance of bacteria of the Lachnospiraceae family in the feces; this family belongs to the Firmicutes phylum, a taxonomic group that has previously been reported to be positively associated with obesity [12].