Since HFD-induced diabetes exacerbated the DR neovascularization in miR-150-/- mice more than in WT (Fig 3), and overexpression of miR-150 significantly down-regulated VEGFR2 in endothelial cells (Fig 4), we postulate that chronic obesity-induced suppression of miR-150 may lead to the inflammation in ocular tissues and further aggravate the DR neovascularization through up-regulating VEGF/VEGFR2. Here, VEGFA is linked to diabetes mellitus.