NFYB and schistosomiasis: Interestingly, the NF-YB(RNAi) phenotype in the male germline is strikingly similar in both S. mediterranea and the trematode S. mansoni. Our findings provide mechanistic insight into the role of NF-YB, show the conserved function of this molecule in the testes of both free-living and parasitic flatworms, and may have implications for combating schistosomiasis.