Although our conclusions are limited by the study of only three mAbs, these mAbs were cloned from 3 different patients and represent three distinct types of pathogenic PV mAbs that have been described in the literature, including anti-Dsg3 IgG1, anti-Dsg3 IgG4, and a cross-reactive anti-Dsg3/Dsg1 IgG. Here, DSG3 is linked to acquired polycythemia vera.