Many efforts have been devoted to uncover genetic aberrations in HCC [8, 14–16], such as point mutation in p53 (TP53) and β–catenin (CTNNB1), etc. However, our understanding of genetic landscape in HCC is still far from complete and the key drivers of HCC tumourigenesis remain poorly to be understood. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.