Since several of the signaling pathways found enriched in our complex are aberrantly activated or deregulated in T-ALL and pharmacological inhibitors to some of the enriched canonical pathways exist, we evaluated whether a functional interaction between the top signaling pathways enriched in our PPP3CA complex and the canonical PPP3CA-NFAT signaling pathway existed. Here, PPP3CA is linked to acute lymphoblastic leukemia.