A caspase-3 and −7 apoptosis assay demonstrated that DDP (2 μg/mL) and Taxol (1 μg/mL)-induced SUNE2 and 5–8F cell apoptosis was attenuated in cells exposed to HDL, revealing the protective role of HDL against chemotherapy in NPC cells (Figure 3E–3F, P < 0.001). This evidence concerns the gene CASP3 and nasopharyngeal carcinoma.