Somes studies have described the potential of macrophages to be self-perpetuated under certain conditions (for example, in the presence of IL-4 during a parasitic infection [Jenkins et al., 2011] or in a M-CSF- or GM-CSF-dependent manner after macrophage depletion [Hashimoto et al., 2013]). This evidence concerns the gene CSF1 and parasitic infectious disease.