In addition, the authors demonstrated by in vitro functional studies that 4 AML-directed drugs (cytarabine, daunorubicin, etoposide, and mitoxantrone) are substrates for OATP1B1, underlining its important role in the PK of multiple anti-AML drugs and suggesting that inherited variability in host transporter function influences the efficacy of therapy [97]. The gene discussed is SLCO1B1; the disease is acute myeloid leukemia.