It was reported that CD133+ A2780, PEO1 EOC cells generate both CD133+ and CD133− daughter cells, exhibiting enhanced resistance to platinum-based therapy in vitro and sorted CD133+ OC cells from A2780 line formed more aggressive tumor xenografts at a lower inoculum than their CD133− progenies on BALB/cAnNCr-nu/nu mice [43]. The gene discussed is PROM1; the disease is neoplasm.