KIT and neoplasm: Interestingly, using cancer cells isolated from human primary OC tissues and ascites, Luo and his colleagues demonstrated that CD117+ OC cells appeared to be highly tumorigenic than CD117− OC cells as it only took approximately 103 cells to be able to self-renew, differentiate, and regenerate tumor in mouse models, and CD117 expression was statistically correlated with resistance to conventional chemotherapy [50].