Based on the analysis of 64 primary high grade ovarian serous carcinoma and peritoneal metastasis, it was demonstrated that patients with high CD117 expression in tumor cells had significantly shorter DFS, high CD133 expression was correlated with shorter DFS and OS, and CD133 was proved to be an independent prognostic factor in the high grade serous carcinomas [82]. The gene discussed is PROM1; the disease is ovarian serous carcinoma.