CD44 and cancer: Similarly, Alvero and colleagues showed that CD44+ cells were enriched in the ascites of OC patients, and the isolated CD44+ cells in mouse xenograftes gave rise to tumors with both CD44+ and CD44− cells, suggesting that those CD44+ cells can differentiate and self-renew with the feature of cancer-initiating cells, in addition, CD44+ EOC cells were demonstrated to be more resistant to paclitaxel and carboplatin compared with CD44− cells.[48].