OPN1SW and hepatocellular carcinoma: However, the difference in the concentrations of serum DLD between the HBsAg-negative group and asymptomatic HBsAg carriers with BCP double mutations or the HBsAg-negative group and the HCC cases with BCP double mutations was significant (t = 4.105, p = 0.0001 and t = 3.714, p = 0.001, respectively), suggesting that the concentrations of serum DLD in those infected with HBV are lower.