NLRP3 and candidiasis: The severe and prolonged defect in macrophage killing by the mmm1 mutant hyphae, coupled with the results from the work of Becker et al. showing that the mmm1 mutant is avirulent in the murine systemic candidiasis model (24), suggested that the NLRP3 inflammasome response is not only regulated on the basis of fungal morphotype but more sensitively tailored to the pathogenicity of the C. albicans strain.