Infections by both wt and E1A mutant viruses caused a substantial drop in TEER by 3 days p.i. Similar results were seen for TEER changes after infection of C57BL6 pmBECs by wt virus and an E3 null mutant virus; i.e., both the wt and mutant viruses caused a drop in TEER. Here, DHTKD1 is linked to infection.