On the other hand, if the in vitro persistence state mimics the QIR state in mouse bladder cells, only the E. coli CFT073 gdhA and sdhA mutants should be less able to cause recurrent UTI, and if so, drugs designed to inactivate the enzymes encoded by gdhA and sdhA might be effective in limiting recurrent urinary tract infection A recurrent UTI mouse model is available for testing these hypotheses (8). The gene discussed is SDHA; the disease is urinary tract infection.