RYR2 and catecholaminergic polymorphic ventricular tachycardia: The autosomal-dominant form of CPVT is caused by mutations in RYR2 (21) encoding for the ryanodine receptor, whereas an autosomal recessive and more rare form is caused by biallelic mutations in CASQ2 (22) that encodes for the calsequestrin-2 protein.