Bagnall and colleagues, conducted a post-mortem WES study in 28 sudden unexplained death cases and identified three rare variants in the major LQTS-associated genes when they focused their analysis on only a small panel of four genes (KCNQ1, KCNH2, SCN5A, and RYR2) (63). The gene discussed is RYR2; the disease is familial long QT syndrome.