MAPK1 and lymphoid neoplasm: Constitutive ERK activity is a hallmark of many B-cell malignancies (Platanias, 2003), consistent with the findings of the mutational analysis presented in Section ‘Analysis of Somatic Mutations Found in the TLR Signaling Network in Lymphoid Neoplasm’ and a whole genome sequencing study in CLL (Wang et al., 2011).