CDC42 and hepatocellular carcinoma: IQGAP 2 associates with Cdc42, Rac1, F-Actin and calmodulin and regulates cell-cell adhesion. Deficiency of IQGAP2 predisposes to development of hepatocellular carcinoma and diabetes (Vaitheesvaran et al., 2014). Silencing of IQGAP2 contributes to gastric cancer metastasis (Jin et al., 2008).