IQGAP 3 interacts with ERK1 and enhances its phosphorylation following treatment with EGF (Nojima et al., 2008; Kunimoto et al., 2009). Overexpression of IQGAP3 promoted tumor cell growth, migration and invasion, whereas suppression of IQGAP3 in lung cancer reduces tumorigenicity (Yang et al., 2014). IQGAP 3 plays a role in FGFR1-Ras-ERK signaling, and loss of function of IQGAP3 affects both cell proliferation and cell motility (Fang et al., 2015). The gene discussed is MAPK3; the disease is lung cancer.