IQGAP 2 associates with Cdc42, Rac1, F-Actin and calmodulin and regulates cell-cell adhesion. Deficiency of IQGAP2 predisposes to development of hepatocellular carcinoma and diabetes (Vaitheesvaran et al., 2014). Silencing of IQGAP2 contributes to gastric cancer metastasis (Jin et al., 2008). Here, RAC1 is linked to diabetes mellitus.