Insulin modulates synaptic plasticity of dopamine neurons to regulate reward function and food intake behavior (Stoufferet al., 2015), as well as behaviors of anxiety and depression (Kleinridderset al., 2015) and hyperinsulinemia may lead to ineffective regulation of dopamine and increased food intake (Liuet al., 2013). The gene discussed is INS; the disease is Hyperinsulinemia.