Treatment of primary murine or human melanocytes or melanoma cell lines with ASIP caused a decrease in eumelanosomes and an inhibition of pigmentation (Hunt and Thody, 1995; Sakai et al., 1997), and binding of ASIP to wild-type MC1R leads to decreased basal tyrosinase activity and decreased tyrosinase and tyrosinase related protein 1, 2, and 3 levels preventing eumelanogenesis (Sakai et al., 1997; Abdel-Malek et al., 2001). The gene discussed is TYR; the disease is melanoma.