These studies in HeLa cells (Chatagnon et al., 2011; Günther et al., 2013), mouse ESCs (Baubec et al., 2013), and breast cancer cell lines (Menafra et al., 2014; Devailly et al., 2015) all showed that MBD2 is broadly associated with densely methylated genomic regions, with no detectable sequence specificity. Here, MBD2 is linked to breast carcinoma.