Therefore, loss of MBD2 may be protective against tumorigenesis by relieving transcriptional repression of hypermethylated tumor suppressor genes such as p14(ARF) and p16(INK4A) that commonly show aberrant methylation in colon cancer cells (Magdinier and Wolffe, 2001; Martin et al., 2008). This evidence concerns the gene CDKN2A and malignant colon neoplasm.