IL22 and exocrine pancreatic carcinoma: The role of IL-22 in tumor development has been reported in several types of cancers, including gastric, lung, colon, hepatocellular, and pancreatic carcinoma, where studies have shown upregulation of IL-22 by tumor-infiltrating lymphocytes in the tumor microenvironment, in addition to the expression of its receptor on cancerous cells (45–49).