Regardless of whether obesity in mice is caused by leptin receptor deficiency (db/db) or high fat diet (HFD – 60% kcal from fat), the loss of skin γδ T cells in obesity results in a reduction in keratinocyte number in the basal layer due to premature keratinocyte differentiation and proliferation (31). The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.