GAPDH and Parkinson disease: Underscoring the significance of this GAPDH/Siah cell death cascade is the demonstration that the anti-Parkinson’s disease drug deprenyl, which reduces neuronal cell death in both in vitro and in vivo models, prevents S-nitrosylation of GAPDH, blocks the GAPDH–Siah interaction, and inhibits GAPDH nuclear translocation (90).