Of interest, preferring D3 receptor agonists (pramipexole and ropinirole) appear to be more likely to cause ICDs in PD patients than relatively non-selective D2/D3 receptor agonists, such as bromocriptine (105), thereby suggesting that D3 dopamine receptors may be predominantly involved in DRT-induced ICDs; but for reasons that are not especially well understood, this provocation appears to be particularly apparent in some, but not all PD patients. The gene discussed is DRD3; the disease is Parkinson disease.