HMOX1 and metabolic syndrome: In our study, we found that OLE treatment during differentiation led to an overexpression of heme oxygenase 1 (HO-1), an inducible enzyme known for its protective and antioxidant effect in vascular disease and in the metabolic syndrome (Novo et al., 2011; Barbagallo et al., 2012, 2014; Marrazzo et al., 2014).