In particular, this study demonstrates that OLE exerts beneficial effects against obesity by overexpressing sirtuin 1 (SIRT-1), peroxisome proliferator-activated receptor alpha (PPARα), and peroxisome proliferator-activated receptor gamma (PPARγ), coactivator 1 alpha (Pgc-1α). Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.