Similarly, treatment withWortmannin or PD98059, a PI3K and MEK1 inhibitors, respectively, induced significantreduction of cell’s migration confirming that tumor cell invasion andproliferation is mediated via activation of PI3K/AKT and ERK pathway(***p < 0.001 vs. Vhl in normoxia;###p < 0.001 vs. Vhl in hypoxia). This evidence concerns the gene AKT1 and neoplasm.