In this tumor, these factors are not only involved in angiogenesis but they alsostimulate tumor cell migration and invasion (Zagzag etal., 2006; Fujiwara et al., 2007).Furthermore, the hypoxic microenvironment and activation of HIF-2α in the core ofsolid tumors induces overexpression of epidermal growth factor receptor (EGFR).Amplification and/or mutations of EGFR are commonly found in GMB. Here, EPAS1 is linked to neoplasm.