A previous study has suggested the involvment of VIP in tumor invasion, but the role ofPACAP and its receptors in this biological context still needs to be elucidated.Considering the relevance of the hypoxic microenvironment in determining tumoraggressivity, in the present study we investigated the effect of these peptides in themodulation of HIFs and EGFR expression, both key elements involved in cell migration andangiogenesis. This evidence concerns the gene VIP and neoplasm.