RELN and schizophrenia: The reduction in Reelin expression occurs most likely through epigenetic mechanisms that affect promoter methylation (Veldic et al., 2004; Grayson et al., 2006) although evidence for genetic association between schizophrenia and REELIN polymorphisms also exists in patient subpopulations (Goldberger et al., 2005; Wedenoja et al., 2008).