EP300 and decreased anxiety-related response: The cyclic AMP response element binding protein (CREB) appears to regulate gene expression via a regulatory loop, with CREB/pCREB/CBP/p300 affecting epigenetic remodeling via histone acetylation, which in turn regulates the expression of crucial pathway genes such as Cbp. We recently observed that acute ethanol-induced anxiolysis appears to be regulated by decreased expression of microRNA-494, and increased expression of its target genes Cbp and p300 in the amygdala of adult rats (Teppen et al., 2015).