In addition, inhibition of EGFR expression promoted apoptosis in CRC cell (8.5-fold of increase or 7.7-fold of increase at caspase 3 activity, 6.5-fold of increase or 7.8-fold of increase at caspase 7 activity in HCT116 or SW480 cells) (Figure 4J–4K). The gene discussed is EGFR; the disease is colorectal carcinoma.