CD8A and B-cell chronic lymphocytic leukemia: Using Student's t-test, a total of 312 CpG sites associated with 206 genes were deemed differentially methylated between CLL and control CD8+ T cells, of which 199 were hypermethylated and 113 were hypomethylated (p < 0.05; an average methylation difference > 0.25) (Figure 5A and Supplementary Table S1).