CD4 and B-cell chronic lymphocytic leukemia: Moreover, patients with the inverted CD4/CD8 ratio had shorter time to first treatment (TTFT) as well as shorter overall survival (OS) when compared to patients with normal CD4/CD8 ratio (p = 0.031 and p = 0.039, respectively) (Figures 1D–1E), a result consistent with previous studies of CLL patient cohorts [18, 19].