In HCC, the function of KLF4 has been characterized as tumor suppressor including: (1) KLF4/VDR signaling pathway may prevent the progress of HCC [10], (2) overexpression of KLF4 inhibits tumor proliferation, invasion and migration in HCC cells and reverts EMT [16], and (3) high expression level of KLF4 is associated with better survival [17]. This evidence concerns the gene KLF4 and hepatocellular carcinoma.